12/19/2023 0 Comments Luca pellegriniHistone H2A-H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin. How does homologous recombination assist in the process of DNA replication?Įvrin C, Maman JD, Diamante A, Pellegrini L, Labib K (2018). How does the molecular machinery of DNA replication cope with obstacles to DNA synthesis? What are the fundamental mechanisms that control DNA synthesis in human cells? Our efforts will advance the molecular understanding of genome biology and our ability to translate such knowledge into medical diagnosis and treatment. We aim to achieve our goal by working out the 3D shape of the protein complexes responsible for the duplication process then using this information to explain their mechanism of action in atomic detail.Įlucidating the molecular basis of DNA replication is important because the genomic instability caused by defective replication is a major cause of diseases such as cancer, as well as developmental and neurodegenerative pathologies. The Pellegrini Group wants to understand at the molecular level how our cells execute the orderly duplication of the genome and how they cope with DNA damage. Genetic inheritance relies on DNA replication, the biochemical process that is responsible for the accurate duplication of our genome and for the repair of lesions that might block DNA synthesis or alter the encoded information. This makes us more versatile and generally more flexible.Molecular mechanisms of genomic stability.Įvery time a cell divides it must duplicate its genome accurately and completely. “Luca Pellegrini can play in both defensive roles on the left, either ahead of a three-man defence, or deeper in a four-man back line. It’s easy to be drawn into making rash predictions, but I’m right about him – he’s turning into a great lad, technically and tactically.” – Bruno Conti, head of Roma youth academy and former Italy international “I remember him when he was just a little kid and his growth has been incredible. “He’s going to become the best full-back in Italy.” – Roberto Muzzi, former coach in the Roma youth academy I didn’t need much time to be convinced to come here.” “Everybody in the world knows the Bundesliga and I’ve seen many Bundesliga games because I love watching football. “Since 2018, when they won the DFB Cup, and since they won the Europa League last year, the whole of Europe has been talking about Eintracht Frankfurt, so of course I knew about them,” he said. In fact, he saw them lift the DFB Cup in 2018, with a win over Bayern Munich, and followed their subsequent campaigns in the UEFA Europa League closely. The football-obsessed Pellegrini had seen the Eagles in action long before contact was made between his agent and the Bundesliga club. Luca Pellegrini did not need to consult with anybody about moving to a club whose fortunes he had been following since 2018. After finally breaking into the Juventus team in 2021/22, he moved to Frankfurt in the summer – also on loan, but with an option for a permanent stay at the Deutsche Bank Park. That convinced Juventus to make their move for Pellegrini in June 2019, although he was shipped out immediately to Cagliari on loan, before spending another brief loan spell at Genoa. Roma stood by him and even extended his contract until 2022, underlining their faith in him, and when he finally did return, he became the youngest defender to provide two assists in Serie A, aged 19. But this injury is definitely not going to stop me.” Six months later, he returned to play for Roma’s reserves, but no sooner had he taken to the field against AC Milan and he was back under the surgeon’s knife due to a fractured knee. “It was just when I was on cloud nine, preparing to leave with the team for a tour of the USA. “It’s not the injury itself which hurts, but the timing of it,” Pellegrini said. It was a particularly testing time for the youngster. Pellegrini suffered a major setback when he tore his cruciate knee ligaments in 2017/18 pre-season – just as he was preparing for a first-team debut.
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